Design and construction of self-hidden and pH-reversed targeting drug delivery nanovehicles via noncovalent interactions to overcome drug resistanceElectronic supplementary information (ESI) available: Additional figures include synthesis route of Ad-lys(Diol)-PCL, PBA-PEG-CD and PEG-CD, 1H NMR spectra of PCL-alkyne, characterization of the click reaction by FT-IR spectra, the CAC of the nanovehicle, expression of over expression of P-pg by Weston blot and in vitro drug release at pH 7.4 and 6.5

Design and construction of self-hidden and pH-reversed targeting drug delivery nanovehicles via noncovalent interactions to overcome drug resistanceElectronic supplementary information (ESI) available: Additional figures include synthesis route of Ad-lys(Diol)-PCL, PBA-PEG-CD and PEG-CD, 1H NMR spectra of PCL-alkyne, characterization of the click reaction by FT-IR spectra, the CAC of the nanovehicle, expression of over expression of P-pg by Weston blot and in vitro drug release at pH 7.4 and 6.5

Using the host-guest interaction between β-cyclodextrin (β-CD) and adamantane (Ad), and borate formation between phenylboronic acid (PBA) and cis -diols, a smart pH-responsible targeting drug delivery nanovehicle, PBA-PEG-CD/Ad-lys(Diol)-PCL, was prepared via one-step self-assembly. Under physiologi...

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Hauptverfasser: Zhao, Dan, Yi, Xiaoqing, Xu, Jiaqi, Yuan, Gongdao, Zhuo, Renxi, Li, Feng
Format: Artikel
Sprache:eng
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