Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipolesElectronic supplementary information (ESI) available: Copies of NMR spectra for all products related to this article; X-ray single crystal structure analysis data for 4aaf. CCDC 1477146. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ra12771a
Under mild reaction conditions, the tandem cycloadditions of cyclic N -sulfonylimines with in situ generated Huisgen 1,4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1,2,3,4-tetrahydropyrimidine-fused benzosultams in low...
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| creator | Zhao, Hong-Wu Chen, Xiao-Qin Pang, Hai-Liang Tian, Ting Li, Bo Song, Xiu-Qing Meng, Wei Yang, Zhao Zhao, Yu-Di Liu, Yue-Yang |
| description | Under mild reaction conditions, the tandem cycloadditions of cyclic
N
-sulfonylimines with
in situ
generated Huisgen 1,4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1,2,3,4-tetrahydropyrimidine-fused benzosultams in low to excellent chemical yields with excellent diastereoselectivities.
The tandem cycloadditions of cyclic
N
-sulfonylimines with in situ generated Huisgen 1,4-dipoles underwent readily, and delivered 1,2,3,4-tetrahydropyrimidine-fused benzosultams in acceptable chemical yields with excellent diastereoselectivities. |
| doi_str_mv | 10.1039/c6ra12771a |
| format | Article |
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N
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in situ
generated Huisgen 1,4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1,2,3,4-tetrahydropyrimidine-fused benzosultams in low to excellent chemical yields with excellent diastereoselectivities.
The tandem cycloadditions of cyclic
N
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N
-sulfonylimines with
in situ
generated Huisgen 1,4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1,2,3,4-tetrahydropyrimidine-fused benzosultams in low to excellent chemical yields with excellent diastereoselectivities.
The tandem cycloadditions of cyclic
N
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N
-sulfonylimines with
in situ
generated Huisgen 1,4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1,2,3,4-tetrahydropyrimidine-fused benzosultams in low to excellent chemical yields with excellent diastereoselectivities.
The tandem cycloadditions of cyclic
N
-sulfonylimines with in situ generated Huisgen 1,4-dipoles underwent readily, and delivered 1,2,3,4-tetrahydropyrimidine-fused benzosultams in acceptable chemical yields with excellent diastereoselectivities.</abstract><doi>10.1039/c6ra12771a</doi><tpages>8</tpages></addata></record> |
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| title | Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipolesElectronic supplementary information (ESI) available: Copies of NMR spectra for all products related to this article; X-ray single crystal structure analysis data for 4aaf. CCDC 1477146. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ra12771a |
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