Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity

Triapine is a promising anticancer thiosemicarbazone which was investigated in multiple clinical trials, where it was active against leukemia but not against solid cancers. This is probably based on insufficient drug levels in the tumor due to a short plasma half-life. Therefore, we encapsulated Tri...

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Veröffentlicht in:	RSC advances 2016-01, Vol.6 (61), p.55848-55859
Hauptverfasser:	Fischer, Britta, Kryeziu, Kushtrim, Kallus, Sebastian, Heffeter, Petra, Berger, Walter, Kowol, Christian R, Keppler, Bernhard K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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