A practical synthesis of chiral tricyclic cyclopenta[]benzofuran, a key intermediate of Beraprost

A novel formal synthesis of Beraprost ( 1 ) is described. The tricyclic cyclopent[ b ]benzofuran core is efficiently prepared from (−)-Corey lactone diol in 12 steps with an overall yield of 37.4%. Key features of the strategy include a ring-closing metathesis reaction and aromatization to form the...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-08, Vol.14 (32), p.7715-7721
Hauptverfasser:	Liu, Xiaoyu, Tian, Chengsen, Jiao, Xiaozhen, Li, Xiaoyu, Yang, Hongguang, Yao, Yangyang, Xie, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzofurans - chemical synthesis Benzofurans - chemistry Cyclopentanes - chemical synthesis Cyclopentanes - chemistry Epoprostenol - analogs & derivatives Epoprostenol - chemical synthesis Epoprostenol - chemistry Molecular Structure
Online-Zugang:	Volltext
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