Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8--erythromycin B

Erythromycin B is structurally very similar to erythromycin A, and also shares its clinically important antibacterial activity. Its potential advantage is that it is much more stable to acid. Both compounds are susceptible to 6-9-enol ether formation, involving loss of a proton from C-8. The enol et...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-06, Vol.14 (26), p.6289-6296
Hauptverfasser:	Bhadra, Pranab K, Hassanzadeh, Abdolreza, Arsic, Biljana, Allison, David G, Morris, Gareth A, Barber, Jill
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