New generation of camptothecin derivatives spontaneously alkylating DNA

9-Aminomethyl derivatives of 7-ethyl-10-hydroxycamptothecin were synthesized. Interaction with a natural DNA octamer was checked using 1 H NMR, PFGSE NMR and MALDI-TOF experiments, which proved covalent binding. Compounds were tested against human cancer cell lines in vitro. All compounds show high...

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Veröffentlicht in:	New journal of chemistry 2016-01, Vol.4 (9), p.7978-7985
Hauptverfasser:	Naumczuk, Beata, Wiktorska, Katarzyna, Lubelska, Katarzyna, Kawcki, Robert, Bocian, Wojciech, Bednarek, Elbieta, Sitkowski, Jerzy, Chilmonczyk, Zdzisaw, Kozerski, Lech
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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