Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface

The high activity of urease, a Ni( ii ) enzyme, has several adverse effects on human health and agriculture, and its modulation needs the use of inhibitors. 1,4-Benzoquinone (BQ) irreversibly inactivates Sporosarcina pasteurii urease (SPU), with first order kinetics for both the inhibitor and the en...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2016-01, Vol.45 (13), p.5455-5459
Hauptverfasser:	Mazzei, L, Cianci, M, Musiani, F, Ciurli, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Active control Benzoquinones - chemistry Binding Sites Crystal structure Crystallography, X-Ray Cysteine Enzymes Inactivation Inhibitors Modulation Molecular Dynamics Simulation Nickel - chemistry Nickel - metabolism Protein Structure, Tertiary Sporosarcina - enzymology Thiols Urease - chemistry Urease - metabolism
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