Ring size effect on the solid state assembly of propargyl substituted hexa- and octacyclic peptoidsElectronic supplementary information (ESI) available. CCDC 1491786-1491791 contain the supplementary crystallographic data for this paper. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6ce01800a

The investigation of the solid state assembly of propargyl substituted hexa- and octacyclic peptoids highlights the effect of ring size in determining the packing arrangement of the macrocycles. A layered arrangement is obtained in the case of the hexacyclic peptoid 1 and a tubular arrangement in the case of the octacyclic peptoid 2 . Guest molecules either intercalate between the layers as in 1 or are located within the peptoid nanotube as in 2 . Hexacyclic peptoids form layers and guest molecules tune the gap between them, octacyclic peptoids form tubes which trap the guest molecules inside.