Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrateElectronic supplementary information (ESI) available: Synthesis of FDP and 7-methylene-FDP, gas chromatograms, MS spectra, 1H-NMR spectra and molecular calculations. See DOI: 10.1039/c6cc08164a

The sesquiterpene cyclase aristolochene synthase from Penicillium roquefortii (PR-AS) has evolved to catalyse with high specificity (92%) the conversion of farnesyl diphosphate (FDP) to the bicyclic hydrocarbon (+)-aristolochene, the natural precursor of several fungal toxins. Here we report that PR...

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Hauptverfasser:	Faraldos, Juan A, Grundy, Daniel J, Cascon, Oscar, Leoni, Stefano, van der Kamp, Marc W, Allemann, Rudolf K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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