Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation

Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation

Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with dif...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-10, Vol.52 (82), p.1222-1225
Hauptverfasser: Petrelli, Antoine, Borsali, Redouane, Fort, Sébastien, Halila, Sami
Format: Artikel
Sprache:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1225
container_issue 82
container_start_page 1222
container_title Chemical communications (Cambridge, England)
container_volume 52
creator Petrelli, Antoine
Borsali, Redouane
Fort, Sébastien
Halila, Sami
description Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs. A tunable release of encapsulated Nile Red from xyloglucan-oligosaccharides- block -polycaprolactone obtained by thiol-(bromo)maleimide click reaction was successfully achieved by mixing their Gluathione-responsiveness.
doi_str_mv 10.1039/c6cc07136h
format Article
fullrecord <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_c6cc07136h</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>c6cc07136h</sourcerecordid><originalsourceid>FETCH-rsc_primary_c6cc07136h3</originalsourceid><addsrcrecordid>eNqFjjsLwjAUhYMo-FzchYw6VFv6UldRnMXBraTpVaM3jeTGR_-9FQRHz_Id-M5wGBsG_jTww8VMJlL6aRAm5wbr1Ii8OJofmp8eL7w0jOI26xJd_DpBPO8wsYPCvLi7lyJH4AWgeoCtOFXkQNOS0xPA8RyNvHJpbgYrDZZrJQERiLuzMuiNc2u0mWiBoLQqoF6Wl_tJOGXKPmsdBRIMvuyx0Wa9X209SzK7WaWFrbLf7_CffwOMrUhS</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Petrelli, Antoine ; Borsali, Redouane ; Fort, Sébastien ; Halila, Sami</creator><creatorcontrib>Petrelli, Antoine ; Borsali, Redouane ; Fort, Sébastien ; Halila, Sami</creatorcontrib><description>Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs. A tunable release of encapsulated Nile Red from xyloglucan-oligosaccharides- block -polycaprolactone obtained by thiol-(bromo)maleimide click reaction was successfully achieved by mixing their Gluathione-responsiveness.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c6cc07136h</identifier><ispartof>Chemical communications (Cambridge, England), 2016-10, Vol.52 (82), p.1222-1225</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Petrelli, Antoine</creatorcontrib><creatorcontrib>Borsali, Redouane</creatorcontrib><creatorcontrib>Fort, Sébastien</creatorcontrib><creatorcontrib>Halila, Sami</creatorcontrib><title>Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation</title><title>Chemical communications (Cambridge, England)</title><description>Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs. A tunable release of encapsulated Nile Red from xyloglucan-oligosaccharides- block -polycaprolactone obtained by thiol-(bromo)maleimide click reaction was successfully achieved by mixing their Gluathione-responsiveness.</description><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFjjsLwjAUhYMo-FzchYw6VFv6UldRnMXBraTpVaM3jeTGR_-9FQRHz_Id-M5wGBsG_jTww8VMJlL6aRAm5wbr1Ii8OJofmp8eL7w0jOI26xJd_DpBPO8wsYPCvLi7lyJH4AWgeoCtOFXkQNOS0xPA8RyNvHJpbgYrDZZrJQERiLuzMuiNc2u0mWiBoLQqoF6Wl_tJOGXKPmsdBRIMvuyx0Wa9X209SzK7WaWFrbLf7_CffwOMrUhS</recordid><startdate>20161006</startdate><enddate>20161006</enddate><creator>Petrelli, Antoine</creator><creator>Borsali, Redouane</creator><creator>Fort, Sébastien</creator><creator>Halila, Sami</creator><scope/></search><sort><creationdate>20161006</creationdate><title>Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation</title><author>Petrelli, Antoine ; Borsali, Redouane ; Fort, Sébastien ; Halila, Sami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c6cc07136h3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrelli, Antoine</creatorcontrib><creatorcontrib>Borsali, Redouane</creatorcontrib><creatorcontrib>Fort, Sébastien</creatorcontrib><creatorcontrib>Halila, Sami</creatorcontrib><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrelli, Antoine</au><au>Borsali, Redouane</au><au>Fort, Sébastien</au><au>Halila, Sami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2016-10-06</date><risdate>2016</risdate><volume>52</volume><issue>82</issue><spage>1222</spage><epage>1225</epage><pages>1222-1225</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs. A tunable release of encapsulated Nile Red from xyloglucan-oligosaccharides- block -polycaprolactone obtained by thiol-(bromo)maleimide click reaction was successfully achieved by mixing their Gluathione-responsiveness.</abstract><doi>10.1039/c6cc07136h</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1359-7345
ispartof Chemical communications (Cambridge, England), 2016-10, Vol.52 (82), p.1222-1225
issn 1359-7345
1364-548X
language
recordid cdi_rsc_primary_c6cc07136h
source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title Redox tunable delivery systems: sweet block copolymer micelles thiol-(bromo)maleimide conjugation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T17%3A39%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-rsc&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Redox%20tunable%20delivery%20systems:%20sweet%20block%20copolymer%20micelles%20thiol-(bromo)maleimide%20conjugation&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Petrelli,%20Antoine&rft.date=2016-10-06&rft.volume=52&rft.issue=82&rft.spage=1222&rft.epage=1225&rft.pages=1222-1225&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c6cc07136h&rft_dat=%3Crsc%3Ec6cc07136h%3C/rsc%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true