A redox stimuli-responsive superparamagnetic nanogel with chemically anchored DOX for enhanced anticancer efficacy and low systemic adverse effects

A reduction-triggered superparamagnetic nanogel was designed for enhancing targeting release but minimizing leakage of drug in the drug-transportation pathway. Doxorubicin (DOX) was first conjugated onto sodium alginate (SA) with a disulfide linker (SA-SS-DOX). SA-SS-DOX was then electrostatically a...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2015-01, Vol.3 (46), p.8949-8962
Hauptverfasser:	Chen, Lidi, Xue, Yanan, Xia, Xiaoyang, Song, Meifang, Huang, Juan, Zhang, Han, Yu, Bo, Long, Sihui, Liu, Yanping, Liu, Lei, Huang, Shiwen, Yu, Faquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Cancer In vitro testing Iron Nanostructure Staining Toxicity
Online-Zugang:	Volltext
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