Redirecting immunity covalently incorporated immunogenic sialic acid on the tumor cell surface

Techniques eliciting anti-tumor immunity are of interest for immunotherapy. We herein report the covalent incorporation of a non-self immunogen into the tumor glycocalyx by metabolic oligosaccharide engineering with 2,4-dinitrophenylated sialic acid ( DNP Sia). This enables marked suppression of pul...

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Veröffentlicht in:	Chemical science (Cambridge) 2016-05, Vol.7 (6), p.3737-3741
Hauptverfasser:	Lin, Bijuan, Wu, Xuanjun, Zhao, Hu, Tian, Yunpeng, Han, Jiahuai, Liu, Jian, Han, Shoufa
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