Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteinsElectronic supplementary information (ESI) available: Figures for eDHFR labeling in vitro and in cells, HPLC analyses of the stabilities of the reagents, CPK models of the reagents, and synthetic methods. See DOI: 10.1039/c5sc00190k

Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteinsElectronic supplementary information (ESI) available: Figures for eDHFR labeling in vitro and in cells, HPLC analyses of the stabilities of the reagents, CPK models of the reagents, and synthetic methods. See DOI: 10.1039/c5sc00190k

A rapid and selective ligand-directed chemical reaction was developed for the acylation of proteins in living cells on the basis of ligand-directed chemistry. By fine tuning the reactivity and stability of the phenyl ester derivatives, we successfully identified ortho -dibromophenyl benzoate as the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Takaoka, Yousuke, Nishikawa, Yuki, Hashimoto, Yuki, Sasaki, Kenta, Hamachi, Itaru
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Schreiben Sie den ersten Kommentar!
Bitte loggen Sie sich zuerst ein