Human serum albumin (HSA) coated liposomal indocyanine green for tumor imaging
In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized. In comparison with ICG solution, the resulting nanoprobe, namely HSA-lipid-ICG NPs, exhibited remarkable improvement in stability as well as higher NIR fluorescence intensity. The in vitro ex...
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| Veröffentlicht in: | RSC advances 2016-02, Vol.6 (18), p.1522-15225 |
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| container_issue | 18 |
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| container_title | RSC advances |
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| creator | Chen, Siqin Yu, Gongjie Zhang, Bo Wang, Yinsong Zhang, Ning Chen, Yan |
| description | In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized. In comparison with ICG solution, the resulting nanoprobe, namely HSA-lipid-ICG NPs, exhibited remarkable improvement in stability as well as higher NIR fluorescence intensity. The
in vitro
experimental results demonstrated that HSA-lipid-ICG NPs were nontoxic at physiologically relevant concentrations and could be efficiently uptaken by MCF-7 cells through endocytosis after 0.5 h incubation. The biodistribution of HSA-lipid-ICG NPs was evaluated in a mouse xenograft model. An optimized tumor contrast was observed after 8 h intravenous administration, while ICG solution had negligible effect. The tumor could be clearly detected and the signal lasted at least up to 24 h after injection. This nanoprobe may potentially serve as an ideal contrast agent for
in vivo
NIR fluorescence imaging.
In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized. |
| doi_str_mv | 10.1039/c5ra25129j |
| format | Article |
| fullrecord | <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_c5ra25129j</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>c5ra25129j</sourcerecordid><originalsourceid>FETCH-rsc_primary_c5ra25129j3</originalsourceid><addsrcrecordid>eNqFjj0LwjAYhIMgWLSLu_COOlST1AY6iiidXHQvsU1LSj5K0gz992YQHL3hueG54RDaEnwkOC9PTeE4LQgthwVKKD6zjGJWrlDq_YBjWHSMJOhRBc0NeOGCBq7eQUsD--p5OUBj-SRaUHK03mquQJrWNjM30gjonRAGOutgCjpSat5L02_QsuPKi_Tba7S7317XKnO-qUcXV26uf9_yf_4DHtQ-kw</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Human serum albumin (HSA) coated liposomal indocyanine green for tumor imaging</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Chen, Siqin ; Yu, Gongjie ; Zhang, Bo ; Wang, Yinsong ; Zhang, Ning ; Chen, Yan</creator><creatorcontrib>Chen, Siqin ; Yu, Gongjie ; Zhang, Bo ; Wang, Yinsong ; Zhang, Ning ; Chen, Yan</creatorcontrib><description>In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized. In comparison with ICG solution, the resulting nanoprobe, namely HSA-lipid-ICG NPs, exhibited remarkable improvement in stability as well as higher NIR fluorescence intensity. The
in vitro
experimental results demonstrated that HSA-lipid-ICG NPs were nontoxic at physiologically relevant concentrations and could be efficiently uptaken by MCF-7 cells through endocytosis after 0.5 h incubation. The biodistribution of HSA-lipid-ICG NPs was evaluated in a mouse xenograft model. An optimized tumor contrast was observed after 8 h intravenous administration, while ICG solution had negligible effect. The tumor could be clearly detected and the signal lasted at least up to 24 h after injection. This nanoprobe may potentially serve as an ideal contrast agent for
in vivo
NIR fluorescence imaging.
In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized.</description><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c5ra25129j</identifier><ispartof>RSC advances, 2016-02, Vol.6 (18), p.1522-15225</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Chen, Siqin</creatorcontrib><creatorcontrib>Yu, Gongjie</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Wang, Yinsong</creatorcontrib><creatorcontrib>Zhang, Ning</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><title>Human serum albumin (HSA) coated liposomal indocyanine green for tumor imaging</title><title>RSC advances</title><description>In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized. In comparison with ICG solution, the resulting nanoprobe, namely HSA-lipid-ICG NPs, exhibited remarkable improvement in stability as well as higher NIR fluorescence intensity. The
in vitro
experimental results demonstrated that HSA-lipid-ICG NPs were nontoxic at physiologically relevant concentrations and could be efficiently uptaken by MCF-7 cells through endocytosis after 0.5 h incubation. The biodistribution of HSA-lipid-ICG NPs was evaluated in a mouse xenograft model. An optimized tumor contrast was observed after 8 h intravenous administration, while ICG solution had negligible effect. The tumor could be clearly detected and the signal lasted at least up to 24 h after injection. This nanoprobe may potentially serve as an ideal contrast agent for
in vivo
NIR fluorescence imaging.
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in vitro
experimental results demonstrated that HSA-lipid-ICG NPs were nontoxic at physiologically relevant concentrations and could be efficiently uptaken by MCF-7 cells through endocytosis after 0.5 h incubation. The biodistribution of HSA-lipid-ICG NPs was evaluated in a mouse xenograft model. An optimized tumor contrast was observed after 8 h intravenous administration, while ICG solution had negligible effect. The tumor could be clearly detected and the signal lasted at least up to 24 h after injection. This nanoprobe may potentially serve as an ideal contrast agent for
in vivo
NIR fluorescence imaging.
In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized.</abstract><doi>10.1039/c5ra25129j</doi><tpages>6</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008- |
| title | Human serum albumin (HSA) coated liposomal indocyanine green for tumor imaging |
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