Effect of ionic composition on the partitioning of organic compounds in octanol-buffer systemsElectronic supplementary information (ESI) available: Table S1: coefficients aio and bio (eqn (1)) of the analysis of the Collander linear relationships between the distribution coefficients of drugs in all different octanol-buffer systems examined (NaPB - sodium phosphate buffer, pH 7.4; UB - universal buffer, pH 7.4, r is the regression coefficient, SD is the standard deviation and N is the number the
The distribution of 29 drug compounds was examined in octanol-buffer systems with eight different ionic compositions at pH 7.4. It was found that the ionic composition of the octanol-buffer system has a noticeable and unpredictable effect on the log D 7.4 values for different compounds. It was esta...
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