Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra01081k
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles ( BZTs ) under microwave irradiation with yields from 80% to 100%. BZT-15 was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. I...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 28821 |
|---|---|
| container_issue | 36 |
| container_start_page | 28814 |
| container_title | |
| container_volume | 5 |
| creator | Pereira Araujo, Débora Santos Morais, Vinicius Stefano de Fátima, Ângelo Modolo, Luzia Valentina |
| description | In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.
BZT-15
was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. Its affinity to bind urease active site is 3-fold higher than that to bind allosteric site(s). The
BZTs 2
,
8-10
,
15
and
16
are described for the first time as soil ureases inhibitors. Overall, these results show the potential of
BZTs
to be used either as lead compound for the design of drugs for treating urease-induced diseases or as additive in urea-based fertilizers to improve N input in soils used for crop production.
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%. |
| doi_str_mv | 10.1039/c5ra01081k |
| format | Article |
| fullrecord | <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_c5ra01081k</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>c5ra01081k</sourcerecordid><originalsourceid>FETCH-rsc_primary_c5ra01081k3</originalsourceid><addsrcrecordid>eNqFjzFLxEAQhRdB8NBr7IWx0-LO3TsveLYa8SqLsw-TZJaMbnbDzkbI_TX_nFsIFoK-5hXfx4On1LnRS6PX25tmE1EbfWfej9RspW-LxUoX2xM1F3nTOcXGrAozU5-ltdww-QQSWh57qFlGZznRosGEbjpQCzL51JGwQLBQkz-E1DEegiMB9C1kyBGGkPIOowMUGCOhZMy-45pTiFI6alIMnhuQcRgc9dnGOGXFhthj4uDhqtzvrgE_kB3WjpawJ4LHl909_H52po4tOqH5d5-qi6fy9eF5EaWphsh9Hq9-9PX__PIvXg2tXX8BAxhxWg</addsrcrecordid><sourcetype>Enrichment Source</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra01081k</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Pereira Araujo, Débora ; Santos Morais, Vinicius Stefano ; de Fátima, Ângelo ; Modolo, Luzia Valentina</creator><creatorcontrib>Pereira Araujo, Débora ; Santos Morais, Vinicius Stefano ; de Fátima, Ângelo ; Modolo, Luzia Valentina</creatorcontrib><description>In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.
BZT-15
was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. Its affinity to bind urease active site is 3-fold higher than that to bind allosteric site(s). The
BZTs 2
,
8-10
,
15
and
16
are described for the first time as soil ureases inhibitors. Overall, these results show the potential of
BZTs
to be used either as lead compound for the design of drugs for treating urease-induced diseases or as additive in urea-based fertilizers to improve N input in soils used for crop production.
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.</description><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c5ra01081k</identifier><language>eng</language><creationdate>2015-03</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Pereira Araujo, Débora</creatorcontrib><creatorcontrib>Santos Morais, Vinicius Stefano</creatorcontrib><creatorcontrib>de Fátima, Ângelo</creatorcontrib><creatorcontrib>Modolo, Luzia Valentina</creatorcontrib><title>Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra01081k</title><description>In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.
BZT-15
was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. Its affinity to bind urease active site is 3-fold higher than that to bind allosteric site(s). The
BZTs 2
,
8-10
,
15
and
16
are described for the first time as soil ureases inhibitors. Overall, these results show the potential of
BZTs
to be used either as lead compound for the design of drugs for treating urease-induced diseases or as additive in urea-based fertilizers to improve N input in soils used for crop production.
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.</description><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFjzFLxEAQhRdB8NBr7IWx0-LO3TsveLYa8SqLsw-TZJaMbnbDzkbI_TX_nFsIFoK-5hXfx4On1LnRS6PX25tmE1EbfWfej9RspW-LxUoX2xM1F3nTOcXGrAozU5-ltdww-QQSWh57qFlGZznRosGEbjpQCzL51JGwQLBQkz-E1DEegiMB9C1kyBGGkPIOowMUGCOhZMy-45pTiFI6alIMnhuQcRgc9dnGOGXFhthj4uDhqtzvrgE_kB3WjpawJ4LHl909_H52po4tOqH5d5-qi6fy9eF5EaWphsh9Hq9-9PX__PIvXg2tXX8BAxhxWg</recordid><startdate>20150324</startdate><enddate>20150324</enddate><creator>Pereira Araujo, Débora</creator><creator>Santos Morais, Vinicius Stefano</creator><creator>de Fátima, Ângelo</creator><creator>Modolo, Luzia Valentina</creator><scope/></search><sort><creationdate>20150324</creationdate><title>Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra01081k</title><author>Pereira Araujo, Débora ; Santos Morais, Vinicius Stefano ; de Fátima, Ângelo ; Modolo, Luzia Valentina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c5ra01081k3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira Araujo, Débora</creatorcontrib><creatorcontrib>Santos Morais, Vinicius Stefano</creatorcontrib><creatorcontrib>de Fátima, Ângelo</creatorcontrib><creatorcontrib>Modolo, Luzia Valentina</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira Araujo, Débora</au><au>Santos Morais, Vinicius Stefano</au><au>de Fátima, Ângelo</au><au>Modolo, Luzia Valentina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra01081k</atitle><date>2015-03-24</date><risdate>2015</risdate><volume>5</volume><issue>36</issue><spage>28814</spage><epage>28821</epage><pages>28814-28821</pages><eissn>2046-2069</eissn><abstract>In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.
BZT-15
was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. Its affinity to bind urease active site is 3-fold higher than that to bind allosteric site(s). The
BZTs 2
,
8-10
,
15
and
16
are described for the first time as soil ureases inhibitors. Overall, these results show the potential of
BZTs
to be used either as lead compound for the design of drugs for treating urease-induced diseases or as additive in urea-based fertilizers to improve N input in soils used for crop production.
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (
BZTs
) under microwave irradiation with yields from 80% to 100%.</abstract><doi>10.1039/c5ra01081k</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2046-2069 |
| ispartof | |
| issn | 2046-2069 |
| language | eng |
| recordid | cdi_rsc_primary_c5ra01081k |
| source | Royal Society Of Chemistry Journals 2008- |
| title | Efficient sodium bisulfite-catalyzed synthesis of benzothiazoles and their potential as ureases inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra01081k |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A46%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-rsc&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficient%20sodium%20bisulfite-catalyzed%20synthesis%20of%20benzothiazoles%20and%20their%20potential%20as%20ureases%20inhibitorsElectronic%20supplementary%20information%20(ESI)%20available.%20See%20DOI:%2010.1039/c5ra01081k&rft.au=Pereira%20Araujo,%20D%C3%A9bora&rft.date=2015-03-24&rft.volume=5&rft.issue=36&rft.spage=28814&rft.epage=28821&rft.pages=28814-28821&rft.eissn=2046-2069&rft_id=info:doi/10.1039/c5ra01081k&rft_dat=%3Crsc%3Ec5ra01081k%3C/rsc%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |