Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA

The design, synthesis and biophysical evaluation of two highly-constrained tricyclic analogues of locked nucleic acid (LNA), which restrict rotation around the C4′-C5′-exocyclic bond (torsion angle γ ) and enhance hydrophobicity in the minor groove and along the major groove, are reported. A structu...

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Veröffentlicht in:	Organic & biomolecular chemistry 2016-01, Vol.14 (6), p.234-24
Hauptverfasser:	Giacometti, Robert D, Salinas, Juan C, Østergaard, Michael E, Swayze, Eric E, Seth, Punit P, Hanessian, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug Design Molecular Conformation Oligonucleotides - chemical synthesis Oligonucleotides - chemistry
Online-Zugang:	Volltext
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