A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-HElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ob01838b
N -Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete...
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| creator | Ivkovic, Jakov Lembacher-Fadum, Christian Breinbauer, Rolf |
| description | N
-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.
N
-Protected α-amino acids can be easily converted directly into chiral α-amino aldehydes in a one-pot procedure by activation with CDI followed by reduction with DIBAL-H. |
| doi_str_mv | 10.1039/c5ob01838b |
| format | Article |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-HElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ob01838b |
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