Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4Electronic supplementary information (ESI) available: Syntheses and characterization data for compounds 2, 4, 5, and 10-21. Numbered thermal ellipsoid plots and X-ray crystallographic data for three compounds, 2, 4, and 17. 1H and 13C NMR spectra of compounds 6, 8, 12, 15, 18 and 21. CCDC 1062374-1062376. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob01557j

Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4Electronic supplementary information (ESI) available: Syntheses and characterization data for compounds 2, 4, 5, and 10-21. Numbered thermal ellipsoid plots and X-ray crystallographic data for three compounds, 2, 4, and 17. 1H and 13C NMR spectra of compounds 6, 8, 12, 15, 18 and 21. CCDC 1062374-1062376. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ob01557j

The chemokine receptor CXCR4 acts as a key cell surface receptor in HIV infections, multiple forms of cancer, and various other pathologies, such as rheumatoid arthritis and asthma. Macrocyclic polyamines and their metal complexes are known to exert anti-HIV activity, many acting as HIV entry inhibi...

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Hauptverfasser: Hamal, Sunil, D'huys, Thomas, Rowley, William F, Vermeire, Kurt, Aquaro, Stefano, Frost, Brian J, Schols, Dominique, Bell, Thomas W
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Sprache:eng
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