Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivityElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ob00565e

The study reports the solid-phase synthesis and biological evaluation of a series of new side chain-to-side chain cyclized opioid peptide analogs of the general structure Tyr-[ d -Xaa-Phe-Phe-Asp]NH 2 , where Xaa = Lys ( 1 ), Orn ( 2 ), Dab ( 3 ), or Dap ( 4 ) (Dab = 2,4-diaminobutyric acid, Dap = 2...

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Hauptverfasser:	Piekielna, Justyna, Kluczyk, Alicja, Gentilucci, Luca, Cerlesi, Maria Camilla, Calo', Girolamo, Tomböly, Csaba, api ski, Krzysztof, Janecki, Tomasz, Janecka, Anna
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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