Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting

Ternary nanocomplexes, composed of bifunctional cationic peptides, lipids and siRNA, as delivery vehicles for siRNA have been investigated. The study is the first to determine the optimal sequence and architecture of the bifunctional cationic peptide used for siRNA packaging and delivery using lipop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular bioSystems 2016-03, Vol.12 (3), p.934-951
Hauptverfasser:	Kudsiova, Laila, Welser, Katharina, Campbell, Frederick, Mohammadi, Atefeh, Dawson, Natalie, Cui, Lili, Hailes, Helen C, Lawrence, M. Jayne, Tabor, Alethea B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cations Cell Line, Tumor Circular Dichroism Dynamic Light Scattering Electrophoretic Mobility Shift Assay Fluorescence Gene Knockdown Techniques Gene Transfer Techniques Humans Liposomes - metabolism Liposomes - ultrastructure Microscopy, Confocal Molecular Sequence Data Neutron Diffraction Peptides - chemistry Peptides - metabolism RNA, Small Interfering - metabolism Scattering, Small Angle Serum - metabolism Static Electricity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!