Aromatic amine N-oxide organometallic compounds: searching for prospective agents against infectious diseasesElectronic supplementary information (ESI) available: KS HOMO and LUMO calculated features for both [M(mpo)(dppf)]+ complexes (Fig. S1). Table of calculated Wiberg bond indices (WBI) for the main bonding interactions in the [M(mpo)(dppf)]+ structures (Table S1). Tables of calculated NPA atomic charges for the mpo moiety in the [M(mpo)(dppf)]+ species and in the free ligand, and for the me

In search of prospective agents against infectious diseases, 1,1′-bis(diphenylphosphino)ferrocene pyridine-2-thiolato-1-oxide M( ii ) hexafluorophosphate compounds [M(mpo)(dppf)](PF 6 ), where M = palladium or platinum, were synthesized and fully characterized in the solid state and in solution using experimental and DFT computational techniques. The compounds are isomorphous and the M( ii ) transition metal ions are in a nearly planar trapezoidal cis -coordination bound to the pyridine-2-thiolato-1-oxide (mpo) and to the 1,1′-bis(diphenylphosphino)ferrocene molecules, both acting as bidentate ligands. Both compounds showed high cytotoxic activity on Trypanosoma cruzi and Mycobacterium tuberculosis (MTB) and acceptable selectivities towards MTB, but good to excellent selectivity index values as anti- T. cruzi compounds. The inclusion of the ferrocene moiety (dppf ligand) improved the selectivity towards the parasite when compared to the previously reported [M(mpo) 2 ] complexes. Related to the probable mechanism of action of the complexes, molecular docking studies on modelled T. cruzi NADH-fumarate reductase ( Tc FR) predicted that both be very good inhibitors of the enzyme. The effect of the compounds on the enzyme activity was experimentally confirmed using T. cruzi protein extracts. According to all obtained results, both [M(mpo)(dppf)](PF 6 ) compounds could be considered prospective anti-trypanosomal agents that deserve further research. 1,1′-Bis(diphenylphosphino)ferrocene pyridine-2-thiolato-1-oxide Pd( ii ) and Pt( ii ) hexafluorophosphate compounds showed cytotoxicity on T. cruzi and M. tuberculosis .