DNA aptamer release from the DNA-SWNT hybrid by protein recognition

Here we show the formation of the complex between a DNA aptamer and a single-walled carbon nanotube (SWNT) and its reaction with its target protein. The aptamer, which is specifically bound with thrombin, the target protein in this study, easily wraps and disperses the SWNT by noncovalent π-π stacki...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (13), p.2784-2787
Hauptverfasser: Yoo, Chang-Hyuk, Jung, Seungwon, Bae, Jaehyun, Kim, Gunn, Ihm, Jisoon, Lee, Junghoon
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container_issue 13
container_start_page 2784
container_title Chemical communications (Cambridge, England)
container_volume 52
creator Yoo, Chang-Hyuk
Jung, Seungwon
Bae, Jaehyun
Kim, Gunn
Ihm, Jisoon
Lee, Junghoon
description Here we show the formation of the complex between a DNA aptamer and a single-walled carbon nanotube (SWNT) and its reaction with its target protein. The aptamer, which is specifically bound with thrombin, the target protein in this study, easily wraps and disperses the SWNT by noncovalent π-π stacking. The hybrid reacts with the target protein specifically and after that the aptamer-thrombin complex is detached from the SWNT.
doi_str_mv 10.1039/c5cc07726e
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Aptamers, Nucleotide - chemistry
Deoxyribonucleic acid
Dispersion
Formations
Nanotubes, Carbon
Proteins
Proteins - chemistry
Recognition
Single wall carbon nanotubes
Stacking
Thrombin
Thrombin - chemistry
title DNA aptamer release from the DNA-SWNT hybrid by protein recognition
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