A peptide array-based serological protein kinase A activity assay and its application in cancer diagnosis

Protein kinase A (PKA) plays a crucial role in several biological processes; however, there is no assay with sufficient sensitivity and specificity to determine serological PKA (sPKA) activity. Here we present an on-chip activity assay that employs cysteine-modified kemptide arrays to determine spec...

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Veröffentlicht in:	Analyst (London) 2015-10, Vol.14 (19), p.6588-6594
Hauptverfasser:	Kong, Deok-Hoon, Jung, Se-Hui, Jeon, Hye-Yoon, Kim, Woo-Jin, Kim, Young-Myeong, Ha, Kwon-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Assaying Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism Cancer Cyclic AMP-Dependent Protein Kinases - blood Cyclic AMP-Dependent Protein Kinases - metabolism Cysteine - chemistry Diagnosis Enzyme Assays - methods Human Humans Kinases Neoplasms - blood Neoplasms - diagnosis Neoplasms - enzymology Octoxynol - chemistry Oligopeptides - chemistry Oligopeptides - metabolism Peptides Protein Array Analysis - methods Proteins Spectrometry, Fluorescence
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