A non-immunosuppressive FK506 analogue with neuroregenerative activity produced from a genetically engineered Streptomyces strainElectronic supplementary information (ESI) available: ESI-MS/MS, 1D- and 2D-NMR spectra of 1. See DOI: 10.1039/c4ra11907j

FK506 exhibits neuroprotective and neuroregenerative activities in addition to its clinically important immunosuppressant properties. The macrolide ring of FK506 is biosynthesized by a hybrid polyketide synthase/nonribosomal peptide synthetase system and is further modified via C-9 oxidation by FkbD...

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Hauptverfasser:	Shinde, Pramod B, Ban, Yeon Hee, Hwang, Jae-yeon, Cho, Yumi, Chen, Yi-Ahn, Cheong, Eunji, Nam, Sang-Jip, Kwon, Ho Jeong, Yoon, Yeo Joon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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