A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluationElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ob01605j
A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu( i ) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the exa...
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| creator | Wei, Gaofei Luan, Weijing Wang, Shuai Cui, Shanshan Li, Fengran Liu, Yongxiang Liu, Yang Cheng, Maosheng |
| description | A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(
i
) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound
3t
possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound
3t
significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study.
A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(
i
) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. |
| doi_str_mv | 10.1039/c4ob01605j |
| format | Article |
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i
) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound
3t
possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound
3t
significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study.
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i
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i
) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound
3t
possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound
3t
significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study.
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i
) catalyzed Huisgen 1,3-dipolar cycloaddition reaction. The anti-proliferative evaluation indicated that some compounds exhibited excellent anti-cancer activity against the examined cancer cell lines. Among all derivatives, compound
3t
possesses the best inhibitory activity against HT1080 cells. A series of pharmacology experiments show that compound
3t
significantly induced HT1080 cell apoptosis. Therefore, this compound can serve as a promising lead candidate for further study.
A series of novel oleanolic acid coupled 1,2,3-triazole derivatives have been designed and synthesized by employing a Cu(
i
) catalyzed Huisgen 1,3-dipolar cycloaddition reaction.</abstract><doi>10.1039/c4ob01605j</doi><tpages>8</tpages></addata></record> |
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| title | A library of 1,2,3-triazole-substituted oleanolic acid derivatives as anticancer agents: design, synthesis, and biological evaluationElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ob01605j |
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