Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidasesElectronic supplementary information (ESI) available: (1) Calculated geometry and NMR parameters for C3′-endo and C2′-endo conformations of [6′R] and [6′S]-epimers of compound 9i. (2) Backbone NMR chemical shift perturbations obtained for cdN complexes (compounds 12d, 13, 15, 31 and 32). (3) Calculated distances of the metal ion and coordinating atoms in 3 differe

Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5′(3′)-nucleotidasesElectronic supplementary information (ESI) available: (1) Calculated geometry and NMR parameters for C3′-endo and C2′-endo conformations of [6′R] and [6′S]-epimers of compound 9i. (2) Backbone NMR chemical shift perturbations obtained for cdN complexes (compounds 12d, 13, 15, 31 and 32). (3) Calculated distances of the metal ion and coordinating atoms in 3 differe

This work describes novel in vitro inhibitors of human mitochondrial (mdN) and cytosolic (cdN) 5′(3′)-deoxynucleotidases. We designed a series of derivatives of the lead compound ( S )-1-[2-deoxy-3,5- O -(phosphonobenzylidene)-β- d - threo -pentofuranosyl]thymine bearing various substituents in the...

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Hauptverfasser: Šimák, Ond ej, Pachl, Petr, Fábry, Milan, Bud šínský, Miloš, Jandušík, Tomáš, Hnízda, Aleš, Skleni ková, Radka, Petrová, Magdalena, Veverka, Václav, ezá ová, Pavlína, Brynda, Ji í, Rosenberg, Ivan
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Sprache:eng
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