Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infectionsElectronic supplementary information (ESI) available: Materials, experimental details, and characterization. See DOI: 10.1039/c4nr07103d
In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into t...
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| creator | Zhang, Fuwu Smolen, Justin A Zhang, Shiyi Li, Richen Shah, Parth N Cho, Sangho Wang, Hai Raymond, Jeffery E Cannon, Carolyn L Wooley, Karen L |
| description | In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations
via
interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced
in vitro
antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.
Degradable polyphosphoester-based polymeric nanoparticles carrying silver cations
via
interactions with alkyne groups has been developed for lung infections. |
| doi_str_mv | 10.1039/c4nr07103d |
| format | Article |
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via
interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced
in vitro
antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.
Degradable polyphosphoester-based polymeric nanoparticles carrying silver cations
via
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via
interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced
in vitro
antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.
Degradable polyphosphoester-based polymeric nanoparticles carrying silver cations
via
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via
interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced
in vitro
antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.
Degradable polyphosphoester-based polymeric nanoparticles carrying silver cations
via
interactions with alkyne groups has been developed for lung infections.</abstract><doi>10.1039/c4nr07103d</doi><tpages>6</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| title | Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infectionsElectronic supplementary information (ESI) available: Materials, experimental details, and characterization. See DOI: 10.1039/c4nr07103d |
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