A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1Electronic supplementary information (ESI) available: Experimental details and characterization data, UV-visible and EPR spectra, table of dissociation constants. See DOI: 10.1039/c4mb00246f

The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys 2 His 2 Cys domains. All three cysteines and the second histidine directly bind Zn( ii ). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involve...

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Hauptverfasser:	Besold, Angelique N, Amick, Deborah L, Michel, Sarah L. J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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