Platinum(ii) clovers targeting G-quadruplexes and their anticancer activitiesElectronic supplementary information (ESI) available: Experimental details, supplementary tables and figures. See DOI: 10.1039/c4dt02760d
Two porphyrin-bridged tetranuclear platinum( ii ) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the re...
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| creator | Zheng, Xiao-Hui Cao, Qian Ding, Yi-Liang Zhong, Yi-Fang Mu, Ge Qin, Peter Z Ji, Liang-Nian Mao, Zong-Wan |
| description | Two porphyrin-bridged tetranuclear platinum(
ii
) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.
The excellent anticancer activity of platinum(
ii
) clovers is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression. |
| doi_str_mv | 10.1039/c4dt02760d |
| format | Article |
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ii
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ii
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ii
) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.
The excellent anticancer activity of platinum(
ii
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Platinum(ii) clovers targeting G-quadruplexes and their anticancer activitiesElectronic supplementary information (ESI) available: Experimental details, supplementary tables and figures. See DOI: 10.1039/c4dt02760d |
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