Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivityElectronic supplementary information (ESI) available: All monodimensional and bidimensional NMR spectra. See DOI: 10.1039/c4dt01156b
An NMR study of a 1 : 1 mixture of a chiral lithium amide ( 4a ) and n -BuLi shows that depending on the solvent employed (Et 2 O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of o -tolualdehyde by these same sp...
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| creator | Barozzino-Consiglio, Gabriella Rouen, Mathieu Oulyadi, Hassan Harrison-Marchand, Anne Maddaluno, Jacques |
| description | An NMR study of a 1 : 1 mixture of a chiral lithium amide (
4a
) and
n
-BuLi shows that depending on the solvent employed (Et
2
O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of
o
-tolualdehyde by these same species.
NMR shows a direct correlation between the concentration of a chiral lithium amide/
n
-BuLi complex and ees of a test reaction. |
| doi_str_mv | 10.1039/c4dt01156b |
| format | Article |
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4a
) and
n
-BuLi shows that depending on the solvent employed (Et
2
O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of
o
-tolualdehyde by these same species.
NMR shows a direct correlation between the concentration of a chiral lithium amide/
n
-BuLi complex and ees of a test reaction.</description><identifier>ISSN: 1477-9226</identifier><identifier>EISSN: 1477-9234</identifier><identifier>DOI: 10.1039/c4dt01156b</identifier><language>eng</language><creationdate>2014-09</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Barozzino-Consiglio, Gabriella</creatorcontrib><creatorcontrib>Rouen, Mathieu</creatorcontrib><creatorcontrib>Oulyadi, Hassan</creatorcontrib><creatorcontrib>Harrison-Marchand, Anne</creatorcontrib><creatorcontrib>Maddaluno, Jacques</creatorcontrib><title>Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivityElectronic supplementary information (ESI) available: All monodimensional and bidimensional NMR spectra. See DOI: 10.1039/c4dt01156b</title><description>An NMR study of a 1 : 1 mixture of a chiral lithium amide (
4a
) and
n
-BuLi shows that depending on the solvent employed (Et
2
O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of
o
-tolualdehyde by these same species.
NMR shows a direct correlation between the concentration of a chiral lithium amide/
n
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4a
) and
n
-BuLi shows that depending on the solvent employed (Et
2
O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of
o
-tolualdehyde by these same species.
NMR shows a direct correlation between the concentration of a chiral lithium amide/
n
-BuLi complex and ees of a test reaction.</abstract><doi>10.1039/c4dt01156b</doi><tpages>1</tpages></addata></record> |
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| source | Alma/SFX Local Collection; Royal Society of Chemistry |
| title | Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivityElectronic supplementary information (ESI) available: All monodimensional and bidimensional NMR spectra. See DOI: 10.1039/c4dt01156b |
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