First enantioselective total synthesis and configurational assignments of suberosenone and suberosanone as potential antitumor agentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc10041g
The first enantioselective total syntheses of two marine sesquiterpenes (1 R )-suberosenone and (1 R )-suberosanone are achieved leading to revision of the AC of natural (1 S )-suberosanone. Key elements of the synthesis include hyperbaric asymmetric Michael addition and highly efficient silver trif...
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| creator | Kousara, Mohammad Ferry, Angélique Le Bideau, Franck Serré, Kathalyn L Chataigner, Isabelle Morvan, Estelle Dubois, Joëlle Chéron, Monique Dumas, Françoise |
| description | The first enantioselective total syntheses of two marine sesquiterpenes (1
R
)-suberosenone and (1
R
)-suberosanone are achieved leading to revision of the AC of natural (1
S
)-suberosanone. Key elements of the synthesis include hyperbaric asymmetric Michael addition and highly efficient silver trifluoroacetate mediated α-alkylation for the formation of ring A.
The first enantioselective syntheses of (1
R
)-suberosenone and (1
R
)-suberosanone are achieved, leading to revision of the AC of a natural (1
S
)-suberosanone. |
| doi_str_mv | 10.1039/c4cc10041g |
| format | Article |
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R
)-suberosenone and (1
R
)-suberosanone are achieved leading to revision of the AC of natural (1
S
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R
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R
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R
)-suberosanone are achieved leading to revision of the AC of natural (1
S
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R
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R
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R
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R
)-suberosanone are achieved leading to revision of the AC of natural (1
S
)-suberosanone. Key elements of the synthesis include hyperbaric asymmetric Michael addition and highly efficient silver trifluoroacetate mediated α-alkylation for the formation of ring A.
The first enantioselective syntheses of (1
R
)-suberosenone and (1
R
)-suberosanone are achieved, leading to revision of the AC of a natural (1
S
)-suberosanone.</abstract><doi>10.1039/c4cc10041g</doi><tpages>4</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | First enantioselective total synthesis and configurational assignments of suberosenone and suberosanone as potential antitumor agentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc10041g |
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