Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl aminesElectronic supplementary information (ESI) available: Further optimisation results, determination of the absolute configuration of compounds 4, experimental details and copies of NMR spectra and HPLC traces. See DOI: 10.1039/c4cc07801b

In the presence of a thiourea catalyst, β-CF 3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of β-CF 3 amine precursors with a tertiary stereocentre at the β-position. This reaction represents the first general catalytic enantioselective approach...

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Hauptverfasser:	Martinelli, Emilie, Vicini, Anna Chiara, Mancinelli, Michele, Mazzanti, Andrea, Zani, Paolo, Bernardi, Luca, Fochi, Mariafrancesca
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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