"Double gating" - a concept for enzyme-responsive imaging probes aiming at high tissue specificityElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc07147f
A new archetype of activatable imaging probe is described that responds in an off-on mode with a fluorescent signal only after being consecutively converted by two different enzymes. Pre-pro-proteins are a well-established concept employed by Nature, but "pre-pro-fluorescent" molecular pro...
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