Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapyElectronic supplementary information (ESI) available: Experimental details and data. See DOI: 10.1039/c4cc04344h

closo -Dodecaborate-encapsulating liposomes were developed as boron delivery vehicles for neutron capture therapy. The use of spermidinium as a counter cation of closo -dodecaborates was essential not only for the preparation of high boron content liposome solutions but also for efficient boron delivery to tumors. Significant anti-tumor effects and longer survivals were observed in the tumor-bearing mice treated with spermidinium closo -dodecaborate-encapsulating liposomes after thermal neutron irradiation.