Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications
Hydrogen sulfide (H 2 S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H 2 S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and c...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2014-10, Vol.5 (8), p.11788-1185 |
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| creator | Zhao, Yu Biggs, Tyler D Xian, Ming |
| description | Hydrogen sulfide (H
2
S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H
2
S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H
2
S in the future. Hydrogen sulfide releasing agents (also known as H
2
S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H
2
S and to be aware of the limitations associated with the choice of donors used to generate H
2
S
in vitro
and
in vivo
. In this review we summarized the developments and limitations of currently available donors including H
2
S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.
This Feature Article provides an overview of currently known hydrogen sulfide donors. |
| doi_str_mv | 10.1039/c4cc00968a |
| format | Article |
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2
S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H
2
S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H
2
S in the future. Hydrogen sulfide releasing agents (also known as H
2
S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H
2
S and to be aware of the limitations associated with the choice of donors used to generate H
2
S
in vitro
and
in vivo
. In this review we summarized the developments and limitations of currently available donors including H
2
S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.
This Feature Article provides an overview of currently known hydrogen sulfide donors.</description><identifier>ISSN: 1359-7345</identifier><identifier>ISSN: 1364-548X</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c4cc00968a</identifier><identifier>PMID: 25019301</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; chemical reactions ; Drug Liberation ; Garlic - chemistry ; Humans ; hydrogen sulfide ; Hydrogen Sulfide - administration & dosage ; Hydrogen Sulfide - chemistry ; Hydrogen Sulfide - pharmacology ; Organothiophosphorus Compounds - administration & dosage ; Organothiophosphorus Compounds - chemistry ; Organothiophosphorus Compounds - pharmacology ; pharmacology ; physiology ; Protective Agents - administration & dosage ; Protective Agents - chemistry ; Protective Agents - pharmacology ; sulfur ; Sulfur Compounds - administration & dosage ; Sulfur Compounds - chemistry ; Sulfur Compounds - pharmacology ; therapeutics</subject><ispartof>Chemical communications (Cambridge, England), 2014-10, Vol.5 (8), p.11788-1185</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-b1d98df49e55d35a18306aedb5932abf4161d166008b7a2fdca2e5df8c9d1fce3</citedby><cites>FETCH-LOGICAL-c566t-b1d98df49e55d35a18306aedb5932abf4161d166008b7a2fdca2e5df8c9d1fce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25019301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Yu</creatorcontrib><creatorcontrib>Biggs, Tyler D</creatorcontrib><creatorcontrib>Xian, Ming</creatorcontrib><title>Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Hydrogen sulfide (H
2
S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H
2
S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H
2
S in the future. Hydrogen sulfide releasing agents (also known as H
2
S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H
2
S and to be aware of the limitations associated with the choice of donors used to generate H
2
S
in vitro
and
in vivo
. In this review we summarized the developments and limitations of currently available donors including H
2
S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.
This Feature Article provides an overview of currently known hydrogen sulfide donors.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>chemical reactions</subject><subject>Drug Liberation</subject><subject>Garlic - chemistry</subject><subject>Humans</subject><subject>hydrogen sulfide</subject><subject>Hydrogen Sulfide - administration & dosage</subject><subject>Hydrogen Sulfide - chemistry</subject><subject>Hydrogen Sulfide - pharmacology</subject><subject>Organothiophosphorus Compounds - administration & dosage</subject><subject>Organothiophosphorus Compounds - chemistry</subject><subject>Organothiophosphorus Compounds - pharmacology</subject><subject>pharmacology</subject><subject>physiology</subject><subject>Protective Agents - administration & dosage</subject><subject>Protective Agents - chemistry</subject><subject>Protective Agents - pharmacology</subject><subject>sulfur</subject><subject>Sulfur Compounds - administration & dosage</subject><subject>Sulfur Compounds - chemistry</subject><subject>Sulfur Compounds - pharmacology</subject><subject>therapeutics</subject><issn>1359-7345</issn><issn>1364-548X</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1P3DAQxS1UBBS49N4qvW2RQu34I3EPSKuoZSshemiRuFmOP4IrbxzsBGn_-xqWLvRSX2ak99PzzDwA3iF4jiDmnxVRCkLOGrkHjhBmpKSkuX3z2FNe1pjQQ_A2pd8wP0SbA3BYUYg4hugIXK82OobeDEWavXXaFItV9fNTEY03MrmhL2QWp_SlUHdm7dIUN4UcdNG54EPvlPSFHEefm8mFIZ2AfSt9MqfP9RjcfPv6q12VVz8uv7fLq1JRxqayQ5o32hJuKNWYStRgyKTRHeW4kp0liCGNGIOw6WpZWa1kZai2jeIaWWXwMbjY-o5ztzZa5RGj9GKMbi3jRgTpxL_K4O5EHx5Edq5qQrLB4tkghvvZpEnk5ZTxXg4mzElUmFaZZbzO6NkWVTGkFI3dfYOgeAxAtKRtnwJYZvjD68F26N-LZ-D9FohJ7dSXBLP-8X-6GLXFfwCM9ZfP</recordid><startdate>20141014</startdate><enddate>20141014</enddate><creator>Zhao, Yu</creator><creator>Biggs, Tyler D</creator><creator>Xian, Ming</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20141014</creationdate><title>Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications</title><author>Zhao, Yu ; Biggs, Tyler D ; Xian, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-b1d98df49e55d35a18306aedb5932abf4161d166008b7a2fdca2e5df8c9d1fce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>chemical reactions</topic><topic>Drug Liberation</topic><topic>Garlic - chemistry</topic><topic>Humans</topic><topic>hydrogen sulfide</topic><topic>Hydrogen Sulfide - administration & dosage</topic><topic>Hydrogen Sulfide - chemistry</topic><topic>Hydrogen Sulfide - pharmacology</topic><topic>Organothiophosphorus Compounds - administration & dosage</topic><topic>Organothiophosphorus Compounds - chemistry</topic><topic>Organothiophosphorus Compounds - pharmacology</topic><topic>pharmacology</topic><topic>physiology</topic><topic>Protective Agents - administration & dosage</topic><topic>Protective Agents - chemistry</topic><topic>Protective Agents - pharmacology</topic><topic>sulfur</topic><topic>Sulfur Compounds - administration & dosage</topic><topic>Sulfur Compounds - chemistry</topic><topic>Sulfur Compounds - pharmacology</topic><topic>therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Yu</creatorcontrib><creatorcontrib>Biggs, Tyler D</creatorcontrib><creatorcontrib>Xian, Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Yu</au><au>Biggs, Tyler D</au><au>Xian, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2014-10-14</date><risdate>2014</risdate><volume>5</volume><issue>8</issue><spage>11788</spage><epage>1185</epage><pages>11788-1185</pages><issn>1359-7345</issn><issn>1364-548X</issn><eissn>1364-548X</eissn><abstract>Hydrogen sulfide (H
2
S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H
2
S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H
2
S in the future. Hydrogen sulfide releasing agents (also known as H
2
S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H
2
S and to be aware of the limitations associated with the choice of donors used to generate H
2
S
in vitro
and
in vivo
. In this review we summarized the developments and limitations of currently available donors including H
2
S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.
This Feature Article provides an overview of currently known hydrogen sulfide donors.</abstract><cop>England</cop><pmid>25019301</pmid><doi>10.1039/c4cc00968a</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2014-10, Vol.5 (8), p.11788-1185 |
| issn | 1359-7345 1364-548X 1364-548X |
| language | eng |
| recordid | cdi_rsc_primary_c4cc00968a |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology chemical reactions Drug Liberation Garlic - chemistry Humans hydrogen sulfide Hydrogen Sulfide - administration & dosage Hydrogen Sulfide - chemistry Hydrogen Sulfide - pharmacology Organothiophosphorus Compounds - administration & dosage Organothiophosphorus Compounds - chemistry Organothiophosphorus Compounds - pharmacology pharmacology physiology Protective Agents - administration & dosage Protective Agents - chemistry Protective Agents - pharmacology sulfur Sulfur Compounds - administration & dosage Sulfur Compounds - chemistry Sulfur Compounds - pharmacology therapeutics |
| title | Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications |
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