Analyte migration electrospray ionization for rapid analysis of complex samples with small volume using mass spectrometryElectronic supplementary information (ESI) available. See DOI: 10.1039/c4an01397b

Complex biological matrices can be effectively removed in the analyte migration process because of their weak solubility in organic solvents. This technique offers other potential advantages, including high-sensitivity and the capability of performing a direct analysis of the components and their metabolites in small-volume raw samples without any pretreatment. Complex biological matrices can be effectively removed in the analyte migration process because of their weak solubility in organic solvents.