Microchip electrophoresis with amperometric detection method for profiling cellular nitrosative stress markers

The overproduction of nitric oxide (NO) in cells results in nitrosative stress due to the generation of highly reactive species such as peroxynitrite and N 2 O 3 . These species disrupt the cellular redox processes through the oxidation, nitration, and nitrosylation of important biomolecules. Microc...

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Veröffentlicht in:	Analyst (London) 2014-07, Vol.139 (13), p.3265-3273
Hauptverfasser:	Gunasekara, Dulan B, Siegel, Joseph M, Caruso, Giuseppe, Hulvey, Matthew K, Lunte, Susan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cellular Electrophoresis Electrophoresis, Microchip - instrumentation Equipment Design Glutathione Glutathione - analysis Hydrogen Peroxide - analysis Macrophages Macrophages - chemistry Markers Mice Nitric Oxide - analysis Nitrites Nitrites - analysis Oxidation-Reduction Peroxynitrous Acid - analysis Separation Stresses Tyrosine - analysis
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