Synthesis of spongistatin 2 employing a new route to the EF fragmentElectronic supplementary information (ESI) available. See DOI: 10.1039/c3sc50304f
An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. The C48-C51 diene side chain, which lacks the chlorine substituent present in spongistatin 1, presented some compatibility issues during target assembly. These were overcome by...
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| container_end_page | 1994 |
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| container_issue | 5 |
| container_start_page | 1989 |
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| container_volume | 4 |
| creator | Kraus, Helmut Français, Antoine O'Brien, Matthew Frost, James Diéguez-Vázquez, Alejandro Polara, Alessandra Baricordi, Nikla Horan, Richard Hsu, Day-Shin Tsunoda, Takashi Ley, Steven V |
| description | An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. The C48-C51 diene side chain, which lacks the chlorine substituent present in spongistatin 1, presented some compatibility issues during target assembly. These were overcome by implementing a late stage Stille cross coupling to construct the diene portion of the natural product.
An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. |
| doi_str_mv | 10.1039/c3sc50304f |
| format | Article |
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| title | Synthesis of spongistatin 2 employing a new route to the EF fragmentElectronic supplementary information (ESI) available. See DOI: 10.1039/c3sc50304f |
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