A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells

In prostate cancer, bone is a frequent site of metastasis; however, the molecular mechanisms of this tumor tropism remain unclear. Here, we integrate a microfluidic coculture platform with multi-photon imaging based techniques to assess both phenotypic cell behavior and FAD fluorescence intensity an...

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Veröffentlicht in:	Integrative biology (Cambridge) 2014-06, Vol.6 (6), p.627-635
Hauptverfasser:	Bischel, Lauren L, Casavant, Benjamin P, Young, Pamela A, Eliceiri, Kevin W, Basu, Hirak S, Beebe, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Cell Line, Tumor Coculture Techniques Flavin-Adenine Dinucleotide - metabolism Humans Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Microfluidics Microscopy, Fluorescence, Multiphoton Prostatic Neoplasms - metabolism Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism
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