Tempranillo-derived grape seed extract induces apoptotic cell death and cell growth arrest in human promyelocytic leukemia HL-60 cells

Although grape seed extract (GSE) has proven to be effective against various cancers, few studies have investigated the effects of GSE on human leukemia. In this study, we analysed the mechanisms involved in the apoptotic effects induced by GSE on human promyelocytic leukemia HL-60 cells. Thus, GSE...

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Veröffentlicht in:	Food & function 2013-12, Vol.4 (12), p.1759-1766
Hauptverfasser:	Espino, Javier, González-Gómez, David, Moreno, Daniel, Fernández-León, María F, Rodríguez, Ana B, Pariente, José A, Delgado-Adámez, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Caspase 3 - genetics Caspase 3 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Grape Seed Extract - administration & dosage HL-60 Cells Humans Leukemia, Myeloid - drug therapy Leukemia, Myeloid - enzymology Leukemia, Myeloid - genetics Leukemia, Myeloid - physiopathology Mitochondria - drug effects Mitochondria - enzymology Mitochondria - metabolism Reactive Oxygen Species - metabolism Vitaceae Vitis - chemistry
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