The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure
The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). The results showed that 90 mg kg 1 LSPCs tre...
Gespeichert in:
| Veröffentlicht in: | Food & function 2013-08, Vol.4 (8), p.1252-1262 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1262 |
|---|---|
| container_issue | 8 |
| container_start_page | 1252 |
| container_title | Food & function |
| container_volume | 4 |
| creator | Duan, Yuqing Wang, Zhigao Zhang, Haihui He, Yuanqing Lu, Rongzhu Zhang, Rui Sun, Guibo Sun, Xiaobo |
| description | The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). The results showed that 90 mg kg
1
LSPCs treatment significantly increased body weight compared with the ELF-EMF group at ELF-EMF exposure and effectively maintained liver index, thymus index, kidney index and spleen index close to normal. A water maze test indicated that learning and memory abilities of the ELF-EMF group deteriorated significantly with ELF-EMF exposure when compared with the control group, but the ELF-EMF + LSPCs90 group had remarkably improved learning and memory abilities compared with the ELF-EMF group. Malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO) and nitric oxide synthase (NOS) mostly exhibited significant increases, while the activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) decreased significantly under ELF-EMF exposure in the ELF-EMF group. LSPCs (especially 60, 90 mg kg
1
) administration decreased MDA, ROS, NO content and lowered NOS activity in LSPCs treatment groups. Furthermore, LSPCs (60, 90 mg kg
1
) treatment significantly augmented GPx, CAT, SOD activity in the hippocampus and serum. Pathological observation showed that number of pyramidal cells of the CA1 and CA3 regions of the hippocampus of the LSPCs treatment groups was significantly greater than the ELF-EMF group. All the data suggested that the LSPCs can effectively prevent learning and memory damage and oxidative damage caused by the ELF-EMF, most likely through the ability of LSPCs to scavenge oxygen free radicals and to stimulate antioxidant enzyme activity.
The preventive effects of lotus seedpod procyanidins on learning and memory damage and oxidative damage in mice at extremely low frequency electromagnetic field exposure. |
| doi_str_mv | 10.1039/c3fo60116a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_rsc_primary_c3fo60116a</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1412526104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-38260b01fd6113e34cb0e4e999a9662c00e16811444de2a70910691bbecfbcc93</originalsourceid><addsrcrecordid>eNqNkTtLBTEQhYMoKmpjr8ROhKt5mbspRXyBYKNgt2STiUZ2kzXZVe_f8ZcavT6wEdNMyPnmZIaD0CYl-5RwdWC4i5JQKvUCWmVEsIk8JLeLX3eh5ArayPmBlMOVqlS1jFYYnxaFklX0en0PuE_wBGHwT4DBOTADjg63cRgzzgC2j7Yg0cx08NaHjGPAJt4F_9Hhu1771JV-rIPF8cVb_SFY3em7ogc7GrC4mWF4GRJ00M6K-TN2CR5HCKa8t-XPFAseYPAGOw-tLXQf85hgHS053WbY-Kxr6Ob05Pr4fHJ5dXZxfHQ5MYKLYcIrJklDqLOSUg5cmIaAAKWUVlIyQwhQWVEqhLDA9JSU_aWiTQPGNcYovoZ2575l1zJYHurOZwNtqwPEMddUUMWnpFLsPyg7ZJISUdC9OWpSzDmBq_vkO51mNSX1e4L1T4IF3v70HZsO7Df6lVcBtuZAyuZb_WWw85de99bxN4Ovr4Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1412526104</pqid></control><display><type>article</type><title>The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Duan, Yuqing ; Wang, Zhigao ; Zhang, Haihui ; He, Yuanqing ; Lu, Rongzhu ; Zhang, Rui ; Sun, Guibo ; Sun, Xiaobo</creator><creatorcontrib>Duan, Yuqing ; Wang, Zhigao ; Zhang, Haihui ; He, Yuanqing ; Lu, Rongzhu ; Zhang, Rui ; Sun, Guibo ; Sun, Xiaobo</creatorcontrib><description>The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). The results showed that 90 mg kg
1
LSPCs treatment significantly increased body weight compared with the ELF-EMF group at ELF-EMF exposure and effectively maintained liver index, thymus index, kidney index and spleen index close to normal. A water maze test indicated that learning and memory abilities of the ELF-EMF group deteriorated significantly with ELF-EMF exposure when compared with the control group, but the ELF-EMF + LSPCs90 group had remarkably improved learning and memory abilities compared with the ELF-EMF group. Malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO) and nitric oxide synthase (NOS) mostly exhibited significant increases, while the activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) decreased significantly under ELF-EMF exposure in the ELF-EMF group. LSPCs (especially 60, 90 mg kg
1
) administration decreased MDA, ROS, NO content and lowered NOS activity in LSPCs treatment groups. Furthermore, LSPCs (60, 90 mg kg
1
) treatment significantly augmented GPx, CAT, SOD activity in the hippocampus and serum. Pathological observation showed that number of pyramidal cells of the CA1 and CA3 regions of the hippocampus of the LSPCs treatment groups was significantly greater than the ELF-EMF group. All the data suggested that the LSPCs can effectively prevent learning and memory damage and oxidative damage caused by the ELF-EMF, most likely through the ability of LSPCs to scavenge oxygen free radicals and to stimulate antioxidant enzyme activity.
The preventive effects of lotus seedpod procyanidins on learning and memory damage and oxidative damage in mice at extremely low frequency electromagnetic field exposure.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/c3fo60116a</identifier><identifier>PMID: 23764910</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Antioxidants - administration & dosage ; Cognition Disorders - drug therapy ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Electromagnetic Fields - adverse effects ; Glutathione Peroxidase - metabolism ; Hippocampus - drug effects ; Hippocampus - enzymology ; Hippocampus - metabolism ; Hippocampus - radiation effects ; Humans ; Learning - drug effects ; Learning - radiation effects ; Lipid Peroxidation - drug effects ; Lipid Peroxidation - radiation effects ; Loteae - chemistry ; Lotus ; Male ; Malondialdehyde - metabolism ; Mice ; Mice, Inbred ICR ; Oxidative Stress - drug effects ; Oxidative Stress - radiation effects ; Plant Extracts - administration & dosage ; Proanthocyanidins - administration & dosage ; Seeds - chemistry ; Superoxide Dismutase - metabolism</subject><ispartof>Food & function, 2013-08, Vol.4 (8), p.1252-1262</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-38260b01fd6113e34cb0e4e999a9662c00e16811444de2a70910691bbecfbcc93</citedby><cites>FETCH-LOGICAL-c434t-38260b01fd6113e34cb0e4e999a9662c00e16811444de2a70910691bbecfbcc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23764910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, Yuqing</creatorcontrib><creatorcontrib>Wang, Zhigao</creatorcontrib><creatorcontrib>Zhang, Haihui</creatorcontrib><creatorcontrib>He, Yuanqing</creatorcontrib><creatorcontrib>Lu, Rongzhu</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Sun, Guibo</creatorcontrib><creatorcontrib>Sun, Xiaobo</creatorcontrib><title>The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). The results showed that 90 mg kg
1
LSPCs treatment significantly increased body weight compared with the ELF-EMF group at ELF-EMF exposure and effectively maintained liver index, thymus index, kidney index and spleen index close to normal. A water maze test indicated that learning and memory abilities of the ELF-EMF group deteriorated significantly with ELF-EMF exposure when compared with the control group, but the ELF-EMF + LSPCs90 group had remarkably improved learning and memory abilities compared with the ELF-EMF group. Malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO) and nitric oxide synthase (NOS) mostly exhibited significant increases, while the activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) decreased significantly under ELF-EMF exposure in the ELF-EMF group. LSPCs (especially 60, 90 mg kg
1
) administration decreased MDA, ROS, NO content and lowered NOS activity in LSPCs treatment groups. Furthermore, LSPCs (60, 90 mg kg
1
) treatment significantly augmented GPx, CAT, SOD activity in the hippocampus and serum. Pathological observation showed that number of pyramidal cells of the CA1 and CA3 regions of the hippocampus of the LSPCs treatment groups was significantly greater than the ELF-EMF group. All the data suggested that the LSPCs can effectively prevent learning and memory damage and oxidative damage caused by the ELF-EMF, most likely through the ability of LSPCs to scavenge oxygen free radicals and to stimulate antioxidant enzyme activity.
The preventive effects of lotus seedpod procyanidins on learning and memory damage and oxidative damage in mice at extremely low frequency electromagnetic field exposure.</description><subject>Animals</subject><subject>Antioxidants - administration & dosage</subject><subject>Cognition Disorders - drug therapy</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Electromagnetic Fields - adverse effects</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - enzymology</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - radiation effects</subject><subject>Humans</subject><subject>Learning - drug effects</subject><subject>Learning - radiation effects</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid Peroxidation - radiation effects</subject><subject>Loteae - chemistry</subject><subject>Lotus</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - radiation effects</subject><subject>Plant Extracts - administration & dosage</subject><subject>Proanthocyanidins - administration & dosage</subject><subject>Seeds - chemistry</subject><subject>Superoxide Dismutase - metabolism</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkTtLBTEQhYMoKmpjr8ROhKt5mbspRXyBYKNgt2STiUZ2kzXZVe_f8ZcavT6wEdNMyPnmZIaD0CYl-5RwdWC4i5JQKvUCWmVEsIk8JLeLX3eh5ArayPmBlMOVqlS1jFYYnxaFklX0en0PuE_wBGHwT4DBOTADjg63cRgzzgC2j7Yg0cx08NaHjGPAJt4F_9Hhu1771JV-rIPF8cVb_SFY3em7ogc7GrC4mWF4GRJ00M6K-TN2CR5HCKa8t-XPFAseYPAGOw-tLXQf85hgHS053WbY-Kxr6Ob05Pr4fHJ5dXZxfHQ5MYKLYcIrJklDqLOSUg5cmIaAAKWUVlIyQwhQWVEqhLDA9JSU_aWiTQPGNcYovoZ2575l1zJYHurOZwNtqwPEMddUUMWnpFLsPyg7ZJISUdC9OWpSzDmBq_vkO51mNSX1e4L1T4IF3v70HZsO7Df6lVcBtuZAyuZb_WWw85de99bxN4Ovr4Q</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Duan, Yuqing</creator><creator>Wang, Zhigao</creator><creator>Zhang, Haihui</creator><creator>He, Yuanqing</creator><creator>Lu, Rongzhu</creator><creator>Zhang, Rui</creator><creator>Sun, Guibo</creator><creator>Sun, Xiaobo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130801</creationdate><title>The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure</title><author>Duan, Yuqing ; Wang, Zhigao ; Zhang, Haihui ; He, Yuanqing ; Lu, Rongzhu ; Zhang, Rui ; Sun, Guibo ; Sun, Xiaobo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-38260b01fd6113e34cb0e4e999a9662c00e16811444de2a70910691bbecfbcc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants - administration & dosage</topic><topic>Cognition Disorders - drug therapy</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Electromagnetic Fields - adverse effects</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - enzymology</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - radiation effects</topic><topic>Humans</topic><topic>Learning - drug effects</topic><topic>Learning - radiation effects</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipid Peroxidation - radiation effects</topic><topic>Loteae - chemistry</topic><topic>Lotus</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - radiation effects</topic><topic>Plant Extracts - administration & dosage</topic><topic>Proanthocyanidins - administration & dosage</topic><topic>Seeds - chemistry</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Yuqing</creatorcontrib><creatorcontrib>Wang, Zhigao</creatorcontrib><creatorcontrib>Zhang, Haihui</creatorcontrib><creatorcontrib>He, Yuanqing</creatorcontrib><creatorcontrib>Lu, Rongzhu</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Sun, Guibo</creatorcontrib><creatorcontrib>Sun, Xiaobo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Yuqing</au><au>Wang, Zhigao</au><au>Zhang, Haihui</au><au>He, Yuanqing</au><au>Lu, Rongzhu</au><au>Zhang, Rui</au><au>Sun, Guibo</au><au>Sun, Xiaobo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>4</volume><issue>8</issue><spage>1252</spage><epage>1262</epage><pages>1252-1262</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days). The results showed that 90 mg kg
1
LSPCs treatment significantly increased body weight compared with the ELF-EMF group at ELF-EMF exposure and effectively maintained liver index, thymus index, kidney index and spleen index close to normal. A water maze test indicated that learning and memory abilities of the ELF-EMF group deteriorated significantly with ELF-EMF exposure when compared with the control group, but the ELF-EMF + LSPCs90 group had remarkably improved learning and memory abilities compared with the ELF-EMF group. Malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO) and nitric oxide synthase (NOS) mostly exhibited significant increases, while the activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) decreased significantly under ELF-EMF exposure in the ELF-EMF group. LSPCs (especially 60, 90 mg kg
1
) administration decreased MDA, ROS, NO content and lowered NOS activity in LSPCs treatment groups. Furthermore, LSPCs (60, 90 mg kg
1
) treatment significantly augmented GPx, CAT, SOD activity in the hippocampus and serum. Pathological observation showed that number of pyramidal cells of the CA1 and CA3 regions of the hippocampus of the LSPCs treatment groups was significantly greater than the ELF-EMF group. All the data suggested that the LSPCs can effectively prevent learning and memory damage and oxidative damage caused by the ELF-EMF, most likely through the ability of LSPCs to scavenge oxygen free radicals and to stimulate antioxidant enzyme activity.
The preventive effects of lotus seedpod procyanidins on learning and memory damage and oxidative damage in mice at extremely low frequency electromagnetic field exposure.</abstract><cop>England</cop><pmid>23764910</pmid><doi>10.1039/c3fo60116a</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2013-08, Vol.4 (8), p.1252-1262 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_rsc_primary_c3fo60116a |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Antioxidants - administration & dosage Cognition Disorders - drug therapy Cognition Disorders - etiology Cognition Disorders - psychology Electromagnetic Fields - adverse effects Glutathione Peroxidase - metabolism Hippocampus - drug effects Hippocampus - enzymology Hippocampus - metabolism Hippocampus - radiation effects Humans Learning - drug effects Learning - radiation effects Lipid Peroxidation - drug effects Lipid Peroxidation - radiation effects Loteae - chemistry Lotus Male Malondialdehyde - metabolism Mice Mice, Inbred ICR Oxidative Stress - drug effects Oxidative Stress - radiation effects Plant Extracts - administration & dosage Proanthocyanidins - administration & dosage Seeds - chemistry Superoxide Dismutase - metabolism |
| title | The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T05%3A35%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_rsc_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20preventive%20effect%20of%20lotus%20seedpod%20procyanidins%20on%20cognitive%20impairment%20and%20oxidative%20damage%20induced%20by%20extremely%20low%20frequency%20electromagnetic%20field%20exposure&rft.jtitle=Food%20&%20function&rft.au=Duan,%20Yuqing&rft.date=2013-08-01&rft.volume=4&rft.issue=8&rft.spage=1252&rft.epage=1262&rft.pages=1252-1262&rft.issn=2042-6496&rft.eissn=2042-650X&rft_id=info:doi/10.1039/c3fo60116a&rft_dat=%3Cproquest_rsc_p%3E1412526104%3C/proquest_rsc_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1412526104&rft_id=info:pmid/23764910&rfr_iscdi=true |