Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactionsElectronic supplementary information (ESI) available: Experimental methods and characterisation of new compounds. See DOI: 10.1039/c3cc49230c

Titanocene carboxylate 1 is an excellent chemoselective reagent for unprecedented α-regioselective Barbier-type reactions. It constitutes the first titanocene( iii ) able to tolerate epoxides and readily reduced carbonyl compounds, such as aromatic and α,β-unsaturated aldehydes. New titanocene( iii ) has been developed for chemoselective α-regioselective Barbier-type reactions, constituting the first titanocene( iii ) able to tolerate epoxides and readily reduced carbonyl compounds.