Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinasesElectronic supplementary information (ESI) available: Experimental details and further characterization. See DOI: 10.1039/c3cc49198f

Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light. Benzoselenadiazole was used as a novel scaffold for construction of microsecond scale responsive photoluminescent probes for protein kinases.