Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondriaElectronic supplementary information (ESI) available: Experimental details, HPLC, ESI-MS, and UV-visible spectra. See DOI: 10.1039/c3cc48847k

Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondriaElectronic supplementary information (ESI) available: Experimental details, HPLC, ESI-MS, and UV-visible spectra. See DOI: 10.1039/c3cc48847k

Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin. Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin.

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Hauptverfasser: Zhao, Linhong, Cheng, Qinqin, Wang, Zhen, Xi, Zhaoyong, Xu, Dechen, Liu, Yangzhong
Format: Artikel
Sprache:eng
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Zusammenfassung:Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin. Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc48847k