Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic coreElectronic supplementary information (ESI) available. See DOI: 10.1039/c3cc46762g

The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied. The amyloidogenic core peptide derived from the TDP-43 C-terminus can disrupt the liposome membrane and induce nascent TDP-43 aggregation.