Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivityElectronic supplementary information (ESI) available: Experimental details, molecular modeling, HPLC chromatograms, and 1H NMR spectra. See DOI: 10.1039/c3cc46675b
A triple mutant of P450pyr monooxygenase (P450pyrTM) catalysed the epoxidation of several para -substituted styrenes as the first enzyme showing high ( R )-enantioselectivity and high conversion, demonstrated a broad substrate range, and showed high enantioselectivity for the epoxidation of an uncon...
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