Importance of the dynamics of adsorption and of a transient interfacial stress on the formation of aggregates of IgG antibodiesElectronic supplementary information (ESI) available: DLS size distribution of IgGp solution as a function of the time of rotation with the needle (Fig. S1); dropwise flow of solutions inducing antibodies aggregation (Fig. S2); AFM evidence of the presence of the IgG monolayer at the mica surface (Fig. S3); dynamic surface tension of 1.5 g L1 antibodies (Fig. S4); fluore

Importance of the dynamics of adsorption and of a transient interfacial stress on the formation of aggregates of IgG antibodiesElectronic supplementary information (ESI) available: DLS size distribution of IgGp solution as a function of the time of rotation with the needle (Fig. S1); dropwise flow of solutions inducing antibodies aggregation (Fig. S2); AFM evidence of the presence of the IgG monolayer at the mica surface (Fig. S3); dynamic surface tension of 1.5 g L1 antibodies (Fig. S4); fluore

It is common knowledge that aggregation of proteins may occur in aqueous solutions under mechanical stress (shaking or high shear), even in solutions that are stable at rest. Addition of surfactants is a practical generic means to prevent this stress-induced aggregation ( e.g. in formulations of the...

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Hauptverfasser: Rudiuk, Sergii, Cohen-Tannoudji, Laetitia, Huille, Sylvain, Tribet, Christophe
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Sprache:eng
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