Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active siteElectronic supplementary information (ESI) available: 1H and 13C NMR spectra of all novel compounds and molecular dockings of 25-38. See DOI: 10.1039/c2ob26736e

Mycobacterium tuberculosis salicylate synthase (MbtI) catalyses the first committed step in the biosynthesis of mycobactin T, an iron-chelating siderophore essential for the virulence and survival of M. tuberculosis . Co-crystal structures of MbtI with members of a first generation inhibitor library...

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Hauptverfasser:	Manos-Turvey, Alexandra, Cergol, Katie M, Salam, Noeris K, Bulloch, Esther M. M, Chi, Gamma, Pang, Angel, Britton, Warwick J, West, Nicholas P, Baker, Edward N, Lott, J. Shaun, Payne, Richard J
Format:	Artikel
Sprache:	eng
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