Total synthesis of the marine toxin phorboxazole A using palladium(ii)-mediated intramolecular alkoxycarbonylation for tetrahydropyran synthesisElectronic supplementary information (ESI) available: Preparations and analytical details of synthetic compounds. See DOI: 10.1039/c2ob25766a
The potent antitumor agent phorboxazole A was synthesized from six subunits comprising C1-C2 ( 115 ), C3-C8 ( 98 ), C9-C19 ( 74 ), C20-C32 ( 52 ), C33-C41 ( 84 ) and C42-C46 ( 85 ). Tetrahydropyrans B and C containing cis -2,6-disubstitution were fabricated via palladium( ii )-mediated intramolecula...
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